I need tips for moving cross county with two young children?

There is a very good possibility that my husband will be getting another job in Louisiana. If he gets it, then we will be moving from Ohio to Louisiana within 2-3 months. I have two small children 21 months and 5 weeks. Does anyone have any suggestions/tips on the best way to move with them, like how to handle 2-3 days on the road with them - how to keep them *and me* sane! How to occupy them, etc. Also, packing tips, what I will need on the road and what I will need once we get there before the movers get there. I am getting apprehensive about this. Please HELP!!